Fox Sets September Premiere for ‘Best Medicine’ Season 2
'Best Medicine' will be back for a second season before 2026 is over, and even better, it’s been given a bumper crop of episodes.
American remakes of British TV shows are usually... let’s say a mixed bag. For every successful Veep or Queer as Folk US, there are half a dozen messy failures like Viva Laughlin, Call Me Kat, Gracepoint, and whatever that American take on Skins was. Happily, however, Fox’s Best Medicine has mercifully ended up on the right side of this trend.
An American spin on popular British comedy Doc Martin, the series stars Josh Charles (The Good Wife) as the titular physician, now reimagined as Martin Best, a former surgeon from Boston who abruptly leaves his position to become a general practitioner in the idyllic Maine village where he used to spend summers as a child. With some help from his Aunt Sarah (Annie Potts) and a sprawling cast of quirky locals, he learns valuable lessons about love, community, and human connection. (Also, he goes to no small number of town festivals and special events along the way.)
The series was one of the 2025 television season’s most popular debuts, and Best Medicine landed a Season 2 renewal well before its first had finished airing. This news probably didn’t surprise anyone familiar with the popularity and staying power of the original; however, it’s the kind of early success that’s becoming increasingly rare in our current television landscape. In fact, Fox has confirmed that, while the series originally debuted as a midseason replacement, it’s moving to a traditional September debut for its second outing, with a series order that's been bumped from 12 to 14 episodes, meaning that we’ll get a couple of extra hours with the denizens of Port Wenn later this year.
(Apparently, everyone has a thing for grumpy medical professionals with blood phobias.)
Per showrunner Liz Tuccillo, Season 2 will pick up five months after the events of the first season finale, which means that Martin will have to contend with both the consequences of the medical board discovering his blood phobia and whatever will they/won’t they business is going on between him and local schoolteacher Louisa Gavin (Abigail Spencer).
Alongside Charles, Spencer and Potts, the series also stars John DiMaggio (The Vampire Lestat) as handyman Bert Large, Carl Shimp (Mayfair Witches) as Bert’s son, Al Large, Josh Segarra (Abbot Elementary) as Louisa’s ex-fiancé Mark Mylow, and Cree Cicchino (Big Sky) as Martin’s receptionist, Elaine Denton.
Stephen Spinella (The Gilded Age) and Jason Veasey (Only Murders in the Building) also return as husbands Greg Garrison and George Brady, the owners of everyone’s favorite local pub, The Salty Dog. Both actors have been upped to series regular status for Season 2.
Tuccillo is also an executive producer alongside Ben Silverman, Rodney Ferrell, and Howard T. Owens of Propagate Content and Doc Martin EPs Mark Crowdy and Philippa Braithwaite.
Best Medicine Season 2 will premiere on Tuesday, September 22, 2026, on Fox and stream the next day on Tubi, with weekly episodes through November. Season 1 is currently streaming on Hulu.
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